tindora / ivy gourd

Bimbika / कुन्द्रू  (Kundru) / तेंडली (Tendli) / ટીંડોરા  (Tindora) / तॊंडली  (Tondli) / கோவை (Kovai) / കോവക്ക  (Kovakka) / దొండ కాయ (Donda kaya) / ತೊಂಡೆ ಕಾಯಿ (Tonde Kayi) / তেলাকুচা (Telakucha) / কুঁঁদরি (Kundri) / তোরুনি  (Toruni) / Ban-kundri / কুণ্ডুলি (Kunduli)

The Leaf Extract of Coccinia grandis (L.) Voigt Accelerated In Vitro Wound Healing by Reducing Oxidative Stress InjuryThe impairment in the regulation of the physiological process in the inflammatory phase of wound healing results in oxidative stress damage, which increases the severity and extends the healing time. In this study, we aimed to evaluate the radical scavenging properties of <i>Coccinia</i> leaf extract and its ability to ameliorate a migration process in vitro. <i>Coccinia</i> is a medicinal plant that was used in ancient times for relieving insect bite itching and swelling. However, the role of <i>Coccinia</i> leaf extract as an antioxidant related to the process of wound healing has never been studied. In this study, we demonstrated that the leaf extract possessed antioxidant properties that acted as a proton donor to neutralize reactive oxygen species with the IC<sub>50</sub> value of 4.85&#x2009;mg/mL of the extract. It could chelate iron with the IC<sub>50</sub> value of 21.39&#x2009;mg/mL of the extract. The leaf extract protected the human fibroblasts and keratinocytes from hydrogen peroxide-induced oxidative stress by increasing cell survival rate by more than 20&#x0025; in all test doses. The protective property was dose-dependently correlated with the decrease in reactive oxygen species formation. In addition, the leaf extract enhanced the cell migration rate of fibroblasts and keratinocytes up to 23&#x0025; compared with vehicle control. The results suggested that <i>Coccinia</i> leaf extract may be a potential herb for increasing the wound healing process with its antioxidant capacity and can be used as an herbal ingredient for the utilization of skincare products.
Identification and Quantification of Key Phytochemicals, Phytohormones, and Antioxidant Properties in Coccinia grandis during Fruit RipeningCoccinia grandis contains secondary metabolites, such as flavonoids, phenolic acids, terpenoids, alkaloids, sterols, and glycosides, which are known to have in vitro antioxidant, antidiabetic, anti-inflammatory, and antidyslipidemic activities. C. grandis fruits change dramatically during ripening, and the differences in the phytochemicals contribute to various uses. This study reports the phytochemical compounds and antioxidant activities during ripening of C. grandis for the first time. Characterizations were conducted on the physiologically active substances in C. grandis fruits at three ripening stages, and a total of 25 peaks were identified. Key phytochemicals in the ripening stages of C. grandis were identified, and the major substances that contributed to antioxidant properties were selected and quantitatively analyzed. Although the concentration of tiliroside increased during aging, hydroxycinnamic acid (chlorogenic and p-coumaric acids), flavonols (rutin), and triterpenes (cucurbitacins B and D) with antioxidant effects decreased. Therefore, phenolic compounds and cucurbitacins dominate immature C. grandis quantitatively. Regarding phytohormones, the gibberellin A4 content decreased as the fruits matured, but indoleacetic acid and salicylic acid increased with fruit maturity. The antioxidant capacities determined by DPPH and ABTS consistently decreased with increasing maturity. Accordingly, the extracts of immature C. grandis fruits have high levels of bioactive compounds and can be used to develop food additives and health supplements.