umrit - ash gourd

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ash gourd

A Literature-Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

Benincasa hispida extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats: Impact on biochemical profile and metabolic patterns

A concise review on Benincasa hispida (Thunb.) Cogn. Plant

A Literature-Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

Influence of Benincasa hispida Peel Extracts on Antioxidant and Anti-Aging Activities, including Molecular Docking Simulation

Benincasa hispida Extract Promotes Proliferation, Differentiation, and Mineralization of MC3T3-E1 Preosteoblasts and Inhibits the Differentiation of RAW 246.7 Osteoclast Precursors

ash/wax gourd

A Literature-Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

A Literature-Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles Benincasa hispida (Thunb.) Cogn. (Cucurbitaceae) is an annual climbing plant, native to Asia with multiple therapeutic uses in traditional medicine. This updated review is aimed at discussing the ethnopharmacological, phytochemical, pharmacological properties, ...

Benincasa hispida extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats: Impact on biochemical profile and metabolic patterns

Benincasa hispida extracts positively regulated high salt‐induced hypertension in Dahl salt‐sensitive rats: Impact on biochemical profile and metabolic patternsBenincasa hispida extract significantly attenuate high salt-induced hypertension in Dahl salt-sensitive rats.

A concise review on Benincasa hispida (Thunb.) Cogn. Plant

A Literature-Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

A Literature-Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles<i>Benincasa hispida</i> (Thunb.) Cogn. (Cucurbitaceae) is an annual climbing plant, native to Asia with multiple therapeutic uses in traditional medicine. This updated review is aimed at discussing the ethnopharmacological, phytochemical, pharmacological properties, and molecular mechanisms highlighted in preclinical experimental studies and toxicological safety to evaluate the therapeutic potential of this genus. The literature from PubMed, Google Scholar, Elsevier, Springer, Science Direct, and database was analyzed using the basic keyword “<i>Benincasa hispida</i>.” Other searching strategies, including online resources, books, and journals, were used. The taxonomy of the plant has been made by consulting “The Plant List”. The results showed that <i>B. hispida</i> has been used in traditional medicine to treat neurological diseases, kidney disease, fever, and cough accompanied by thick mucus and to fight intestinal worms. The main bioactive compounds contained in <i>Benincasa hispida</i> have cytotoxic, anti-inflammatory, and anticancer properties. Further safety and efficacy investigations are needed to confirm these beneficial therapeutic effects and also future human clinical studies.

Influence of Benincasa hispida Peel Extracts on Antioxidant and Anti-Aging Activities, including Molecular Docking Simulation

Influence of Benincasa hispida Peel Extracts on Antioxidant and Anti-Aging Activities, including Molecular Docking SimulationBenincasa hispida peel, a type of postconsumer waste, is considered a source of beneficial phytochemicals. Therefore, it was subjected to investigation for biological activities in this study. B. hispida peel was extracted using 95% v/v, 50% v/v ethanol and water. The obtained extracts were B95, B50 and BW. B95 had a high flavonoid content (212.88 ± 4.73 mg QE/g extract) and phenolic content (131.52 ± 0.38 mg GAE/g extract) and possessed high antioxidant activities as confirmed by DPPH, ABTS and lipid peroxidation inhibition assays. Moreover, B95 showed inhibitory effects against collagenase and hyaluronidase with values of 41.68 ± 0.92% and 29.17 ± 0.66%, which related to anti-aging activities. Via the HPLC analysis, one of the potential compounds found in B95 was rutin. Molecular docking has provided an understanding of the molecular mechanisms underlying the interaction of extracts with collagenase and hyaluronidase. All extracts were not toxic to fibroblast cells and did not irritate the hen’s egg chorioallantoic membrane, which indicated its safe use. In conclusion, B. hispida peel extracts are promising potential candidates for further use as antioxidant and anti-aging agents in the food and cosmetic industries.

Benincasa hispida Extract Promotes Proliferation, Differentiation, and Mineralization of MC3T3-E1 Preosteoblasts and Inhibits the Differentiation of RAW 246.7 Osteoclast Precursors

Benincasa hispida Extract Promotes Proliferation, Differentiation, and Mineralization of MC3T3-E1 Preosteoblasts and Inhibits the Differentiation of RAW 246.7 Osteoclast PrecursorsOwing to global population aging, instances of bone metabolic diseases have increased. Consequently, interest in natural and functional plant food products for the prevention and treatment of osteoporosis is also increasing. In this study, we determine the potential therapeutic effects of Benincasa hispida extract (HR1901-W) on osteoblast and osteoclast differentiation. The potential preventive effects of Benincasa hispida in osteoporosis have not previously been reported. We identified and analyzed 2-furoic acid, a chemical component of HR1901-W. We evaluated whether HR1901-W promoted osteogenesis in the MC3T3-E1 cell line and whether it inhibited the differentiation of RAW 264.7 macrophage cells (osteoblast precursors). We observed that HR1901-W promoted significantly high dose-dependent proliferation and extracellular matrix mineralization in MC3T3-E1 cells. In fact, increased cell proliferation was found to be associated with increased protein expression of factors related to osteoblast differentiation, including alkaline phosphatase, osteocalcin, and runt-related transcription factor 2. On the other hand, macrophage colony-stimulating factor (10 ng/mL) and nuclear factor-κB ligand (100 ng/mL) treated differentiated RAW264.7 macrophages exhibited a significant reduction in tartrate-resistant acid phosphatase activity. Taken together, our results indicate that HR1901-W is a promising candidate of functional materials that regulate the balance between bone-forming osteoblasts and bone-resorbing osteoclasts to prevent osteoporosis.

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