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diabetes

Ancient Wheat Diet Delays Diabetes Development in a Type 2 Diabetes Animal Model

Evaluation of antioxidative and diabetes-preventive properties of an ancient grain, KAMUT® khorasan wheat, in healthy volunteers

Biomolecular Characterization of Putative Antidiabetic Herbal Extracts

Red clover extract exerts antidiabetic and hypolipidemic effects in db/db mice

Plant foods in the management of diabetes mellitus: vegetables as potential hypoglycaemic agents

Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus

Tapping the nutraceutical potential of industrial hemp against arthritis and diabetes - A comprehensive review

Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats

Environmental toxicant exposures and type 2 diabetes mellitus: Two interrelated public health problems on the rise

Toxins and Diabetes Mellitus: An Environmental Connection?

Cannabidiol (CBD) Use in Type 2 Diabetes: A Case Report

Evaluation of mulberry leaves’ hypoglycemic properties and hypoglycemic mechanisms

Mulberry leaf active components alleviate type 2 diabetes and its liver and kidney injury in db/db mice through insulin receptor and TGF-β/Smads signaling pathway

diabetes

Ancient Wheat Diet Delays Diabetes Development in a Type 2 Diabetes Animal Model

Ancient Wheat Diet Delays Diabetes Development in a Type 2 Diabetes Animal ModelAIM: The main objective was to investigate the physiological effects of ancient wheat whole grain flour diets on the development and progression of type 2 diabetes in Zucker diabetic fatty (ZDF) rats, and specifically to look at the acute glycemic responses. ...

Evaluation of antioxidative and diabetes-preventive properties of an ancient grain, KAMUT® khorasan wheat, in healthy volunteers

Evaluation of antioxidative and diabetes-preventive properties of an ancient grain, KAMUT® khorasan wheat, in healthy volunteersRecently, there was an increasing interest on the use of ancient grains because of their better health-related composition. The aim of this study was to evaluate in healthy human subjects the antioxidative and diabetes-preventive properties of ancient ...

Biomolecular Characterization of Putative Antidiabetic Herbal Extracts

Biomolecular Characterization of Putative Antidiabetic Herbal ExtractsInduction of GLUT4 translocation in the absence of insulin is considered a key concept to decrease elevated blood glucose levels in diabetics. Due to the lack of pharmaceuticals that specifically increase the uptake of glucose from the blood circuit, application of natural compounds might be an alternative strategy. However, the effects and mechanisms of action remain unknown for many of those substances. For this study we investigated extracts prepared from seven different plants, which have been reported to exhibit anti-diabetic effects, for their GLUT4 translocation inducing properties. Quantitation of GLUT4 translocation was determined by total internal reflection fluorescence (TIRF) microscopy in insulin sensitive CHO-K1 cells and adipocytes. Two extracts prepared from purslane (Portulaca oleracea) and tindora (Coccinia grandis) were found to induce GLUT4 translocation, accompanied by an increase of intracellular glucose concentrations. Our results indicate that the PI3K pathway is mainly responsible for the respective translocation process. Atomic force microscopy was used to prove complete plasma membrane insertion. Furthermore, this approach suggested a compound mediated distribution of GLUT4 molecules in the plasma membrane similar to insulin stimulated conditions. Utilizing a fluorescent actin marker, TIRF measurements indicated an impact of purslane and tindora on actin remodeling as observed in insulin treated cells. Finally, in-ovo experiments suggested a significant reduction of blood glucose levels under tindora and purslane treated conditions in a living organism. In conclusion, this study confirms the anti-diabetic properties of tindora and purslane, which stimulate GLUT4 translocation in an insulin-like manner.

Red clover extract exerts antidiabetic and hypolipidemic effects in db/db mice

Red clover extract exerts antidiabetic and hypolipidemic effects in db/db miceTo investigate the effects of red clover extract on the blood glucose and lipid levels of type 2 diabetic db/db mice, male db/db mice were treated with this extract for a period of 5 weeks. The red clover extract had a significant effect on lowering the blood glucose levels of db/db mice. The serum triglyceride, serum total cholesterol, liver triglyceride and liver cholesterol levels for diabetic mice receiving red clover extract were significantly lower compared to those of the untreated diabetic mice. The mRNA expression of two target genes transcriptionally regulated by peroxisome proliferator-activated receptor (PPAR)γ was determined by quantitative real-time RT-PCR, and red clover extract was observed to significantly upregulate hepatic glucokinase and CD36 expression. Four target genes transcriptionally regulated by PPARα were also assayed, and red clover extract was observed to significantly downregulate hepatic apolipoprotein C3 expression whereas it had no significant effect on apolipoprotein A5, acetyl CoA oxidase and carnitine palmitoyl transferase-1 expression. In addition, hepatic mRNA expression of fatty acid synthase was also observed to be downregulated by red clover extract treatment. Thus, we conclude that red clover extract significantly improves the glucose and lipid homeostasis in db/db diabetic mice and that these effects are achieved at least in part by activating hepatic PPARα/γ and by inhibiting hepatic fatty acid synthase.

Plant foods in the management of diabetes mellitus: vegetables as potential hypoglycaemic agents

Plant foods in the management of diabetes mellitus: vegetables as potential hypoglycaemic agents - PubMedVegetables are among the numerous plant adjuncts tried for the treatment of diabetes mellitus. A few vegetables that are commonly consumed in India have been claimed to possess antidiabetic potency. In recent years, there has been a renewed interest to screen such plant food materials, for a possibl …

Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus

Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitusDiabetes mellitus (DM) type 2 is amongst the most common chronic diseases, being responsible for various problems in humans and contributing to increased mortality rates worldwide. Fructooligosaccharide, which can be produced from the roots of burdock ...

The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer’s Disease

The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer’s DiseaseT2DM is a complex metabolic disorder characterized by hyperglycemia and glucose intolerance. It is recognized as one of the most common metabolic disorders and its prevalence continues to raise major concerns in healthcare globally. Alzheimer’s disease (AD) is a gradual neurodegenerative brain disorder characterized by the chronic loss of cognitive and behavioral function. Recent research suggests a link between the two diseases. Considering the shared characteristics of both diseases, common therapeutic and preventive agents are effective. Certain bioactive compounds such as polyphenols, vitamins, and minerals found in vegetables and fruits can have antioxidant and anti-inflammatory effects that allow for preventative or potential treatment options for T2DM and AD. Recently, it has been estimated that up to one-third of patients with diabetes use some form of complementary and alternative medicine. Increasing evidence from cell or animal models suggests that bioactive compounds may have a direct effect on reducing hyperglycemia, amplifying insulin secretion, and blocking the formation of amyloid plaques. One plant that has received substantial recognition for its numerous bioactive properties is Momordica charantia (M. charantia), otherwise known as bitter melon, bitter gourd, karela, and balsam pear. M. charantia is utilized for its glucose-lowering effects and is often used as a treatment for diabetes and related metabolic conditions amongst the indigenous populations of Asia, South America, India, and East Africa. Several pre-clinical studies have documented the beneficial effects of M. charantia through various postulated mechanisms. Throughout this review, the underlying molecular mechanisms of the bioactive components of M. charantia will be highlighted. More studies will be necessary to establish the clinical efficacy of the bioactive compounds within M. charantia to effectively determine its pertinence in the treatment of metabolic disorders and neurodegenerative diseases, such as T2DM and AD.

Tapping the nutraceutical potential of industrial hemp against arthritis and diabetes - A comprehensive review

Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats

Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats.pdf

Environmental toxicant exposures and type 2 diabetes mellitus: Two interrelated public health problems on the rise

Environmental toxicant exposures and type 2 diabetes mellitus Two interrelated public health problems on the rise.pdf

Toxins and Diabetes Mellitus: An Environmental Connection?

Toxins and Diabetes Mellitus An Environmental Connection

Cannabidiol (CBD) Use in Type 2 Diabetes: A Case Report

Cannabidiol (CBD) Use in Type 2 Diabetes.pdf

Evaluation of mulberry leaves’ hypoglycemic properties and hypoglycemic mechanisms

Mulberry leaf active components alleviate type 2 diabetes and its liver and kidney injury in db/db mice through insulin receptor and TGF-β/Smads signaling pathway

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